Endocrine Abstracts

Objective: The aim of the study was to determine the prevalence of subclinical late-onset hypogonadism (SLOH) and erectile dysfunctions in the elderly men with diabetes type 2.Material and methods: We investigated 51 men mean aged 68.3 years with diabetes type 2 according ADA recommendations. Androgens concentrations, BMI, HbA1C were measured. All of men were treated with oral antidiabetic drugs or insulin. LOH was expected on the basis of low testostero...

Objective: The role of testosterone in the anatomy and physiology of erection is becoming clear. Erectile dysfunctions (ED) are very common observed in men with diabetes mellitus type 2 (DM2). The aim of the study was to determine the efficacy of testosterone adminisartions in elderly men with ED and DM2.Material and methods: We investigated 41 men mean aged 65.4 years with late onset hypogonadism according Polish Endocrine Society recommendations and DM...

Objectives: The aim of this study was to analyze the influence of DHEA therapy on fibrinogen, plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) plasma concentrations in men with decreased serum DHEAS levels and angiographically verified coronary heart disease (CHD).Material and methods: The study included thirty men aged 41–60 years (mean age 52±0.90 yr) with serum DHEAS concentration <2000 μg/l, who were...

Introduction: In elderly men testosterone and DHEAS deficiency is often observed, also changes of body composition and metabolic disturbances are common disorders.Objectives: The aim of this study was to analyze the association between testosterone and DHEAS deficiency and waist/hip ratio (WHR) and also levels of glucose, insulin, HOMA and FG/FI ratio in elderly men as well as analysis, whether these sex hormones influent on measured parameters separatel...

A 76-year obese women with diabetes mellitus t II, hypertension and urolithiasis was referred to our clinic for reason of high cortisol levels, which were detected in regional hospital, two days after cystoscopy and catheterization of right ureter. Cortisolemia was 35 μg% at 8.00 and 37 μg % at 22.00. Short dexamethasone test didn’t cause cortisol suppression (cortisolemia after 1 mg DXM was 27 μg %). After two days of dexamethasone (4×2 mg) blood cort...

Dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) are weak adrenal androgens, which may exert anabolic effect on bone tissue.We have measured serum DHEAS levels and bone mineral density in lumbar spine and femoral neck in 131 healthy, agile, postmenopausal women aged 59–89. There were no diseases which aggravate bone loss and no hormonal replacement therapy in medical history of participants.Women were divided into groups...

Adrenal cortex scintigraphy has been used as early as in the 1970s, however, in recent years, it has been a rarely performed and unappreciated examination. In fact, this examination does not provide a perfect view on morphology of adrenal glands, however it provides an assessment of the examined tumor’s function. The aim of this work is to present our experience with adrenal cortex scintigraphy in assessment of adrenal tumors.We present a series of ...

Objective: According to some authors a higher incidence of subclinical hypercortisolaemia is found among patients with bilateral adrenal tumors with benign phenotype than with unilateral ones. The question is whether all patients with bilateral adrenal tumors and subclinical hypercortisolemia should undergo surgery and, if yes, which of the tumors should be removed first.Patients and methods: The investigated group consisted of 25 patients with benign bi...

Isolated hypogonadotropic hypogonadism (IHH) is caused by impaired gonadoliberin (GnRH) gene regulation, synthesis or secretion of GnRH. Genetic factors of more than 50% of the IHH are still unknown. One the most common types of IHH is the Kallmann syndrome (KS) associated with anosmia or hyposmia. In view of technological progress and new possibilities for detecting changes in human genome a comprehensive targeted analysis using next-generation sequencing (NGS) was carried ou...